What question did this study set out to answer?

To report the occurrence of SBRT-induced bone flare in a patient with oligometastatic prostate cancer.

April 10, 2026

Stereotactic Body Radiation Therapy (SBRT)-Induced 68Ga-PSMA PET Bone Flare

Key Points

To report the occurrence of SBRT-induced bone flare in a patient with oligometastatic prostate cancer.
Patient underwent radical prostatectomy and SBRT for a right pubic bone metastasis.
PSMA PET imaging was conducted before and after SBRT, specifically four weeks post-treatment.
PSA levels were monitored to assess disease progression.
Post-SBRT, PSMA PET showed increased uptake at the treatment site despite a significant PSA decline.
Initial imaging indicated a 92% reduction in PSA levels, but new osseous metastases and rising PSA were later observed confirming disease progression.
The case represents a novel observation of bone flare after SBRT treatment.

Abstract

A 65-year-old man with oligometastatic prostate cancer underwent radical prostatectomy and stereotactic body radiation therapy (SBRT) to a right pubic bone metastasis. Four weeks after SBRT, PSMA PET showed increased extent and intensity of uptake at the treated site, despite a 92% PSA decline (8.5 to 0.7 ng/mL) and no new lesions. Later imaging confirmed resolution of uptake, consistent with bone flare, but revealed multiple new osseous metastases and rising PSA (2.8 ng/mL), indicating progression. To our knowledge, this is the first reported case of SBRT-induced bone flare, highlighting the need for cautious interpretation of early posttreatment PSMA PET.

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Discussion

Cite this study

Marulanda-Corzo et al. (Tue,) studied this question.

synapsesocial.com/papers/69d8967d6c1944d70ce07e8c — DOI: https://doi.org/10.1097/rlu.0000000000006447

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Authors

Valentina Marulanda-Corzo

Cornell University

Preeti Kakkar

Cornell University

Arman Sharbatdaran

Cornell University

Journals

Clinical Nuclear Medicine

Actions

Institutions

Cornell University

Presbyterian Hospital

Lander Institute

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Stereotactic Body Radiation Therapy (SBRT)-Induced 68Ga-PSMA PET Bone Flare

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

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Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider