June 27, 2005Open Access

Remifentanil-induced Postoperative Hyperalgesia and Its Prevention with Small-dose Ketamine

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Abstract

A relatively large dose of intraoperative remifentanil triggers postoperative secondary hyperalgesia. Remifentanil-induced hyperalgesia was prevented by small-dose ketamine, implicating an N-methyl-d-aspartate pain-facilitator process.

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Joly et al. (Mon,) studied this question.

synapsesocial.com/papers/69d900cdf544bba627bedc40 https://doi.org/https://doi.org/10.1097/00000542-200507000-00022

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4The Efficacy of Intravenous 0.15 Versus 0.25 mg/kg Intraoperative Morphine for Immediate Postoperative Analgesia After Remifentanil-Based Anesthesia for Major Surgery2000 · 82 citations
5N-Methyl-d-aspartate receptors are implicated in hyperresponsiveness following naloxone reversal of alfentanil in isolated rat spinal cord1995 · 30 citations

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