Provides a transcriptional framework identifying chromatin landscape alterations that limit the reinduction of regenerative programs in adult mammalian cardiomyocytes.
This work provides a comprehensive framework and transcriptional resource of multiple cardiac cell populations during cardiac development, repair, and regeneration. Our findings define a regulatory program underpinning the neonatal regenerative state and identify alterations in the chromatin landscape that could limit reinduction of the regenerative program in adult cardiomyocytes.
Quaife-Ryan et al. (Sat,) studied this question.