Does acetylcholine administration affect coronary endothelin concentration and vasoconstriction in humans with coronary endothelial dysfunction?
Endothelin is elevated in humans with coronary endothelial dysfunction and increases further with acetylcholine, supporting its role as an early participant and marker in coronary endothelial dysfunction.
This study demonstrates that endothelin immunoreactivity is enhanced in the coronary and systemic circulation in humans with coronary endothelial dysfunction. Moreover, acetylcholine further increased coronary endothelin concentration in patients with coronary endothelial dysfunction and was associated with coronary vasoconstriction. These observations strongly support a role for endothelin as an early participant in and marker for coronary endothelial dysfunction in humans.
Lerman et al. (Wed,) studied this question.
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