January 14, 2009Open Access

Acyl-coenzyme A:cholesterol acyltransferases

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Abstract

The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.

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Cite This Study

Chang et al. (Wed,) studied this question.

synapsesocial.com/papers/69da7e40ae64bec32b836017 https://doi.org/https://doi.org/10.1152/ajpendo.90926.2008

Discussion

Journals

AJP Endocrinology and Metabolism

Institutions

Dartmouth College

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