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Poly(methylmethacrylate) (PMMA) is a widely used material in dental applications, particularly as denture resins. Due to thermally unstable and wet oral cavity, the implanted PMMA based resins occasionally deform and grow bacterial biofilms at the interface between oral cavity and the biomaterial. Several strategies attempted earlier to improve the bacterial resistance and mechanical performance of PMMA. Poly(ethyleneimine) (PEI) is a hyperbranched cationic polymer shown earlier to improve antibacterial activity of resins but do not improve mechanical properties of the resins alone, while silk fibroin (SF) is a natural biopolymer with unique material properties. In this study, we combined SF and PEI towards development of antibacterial and mechanically superior PMMA based materials towards overcoming its drawbacks. Using polyblend electrospinning to combine SF, PEI and PMMA, we successfully developed intrinsically antibacterial and mechanically reinforced nanofiber mats. We propose that the resulting nanofiber mats have the potential to be incorporated into PMMA based denture resin materials to overcome the problems of patients and improve their quality of life.
Karatepe et al. (Wed,) studied this question.