Does coagulation factor Xa stimulate interleukin-8 release in the context of acute myocardial infarction?
Coagulation factor Xa stimulates proinflammatory interleukin-8 release via PAR-1 activation, suggesting a mechanistic link between coagulation and systemic inflammation in acute myocardial infarction.
Our data suggest that coagulation FXa may contribute to proinflammatory changes in AMI by stimulation of IL-8 release. Therapeutic inhibition of the proinflammatory effects of FXa may improve the clinical course in AMI. This study investigates the relationship between the activation of coagulation and systemic inflammatory changes in acute myocardial infarction. Tissue factor pathway inhibitor factor Xa but not F1+2 plasma levels were associated with circulating interleukin-8. In vitro factor Xa stimulated interleukin-8 and monocyte chemoattractant protein-1 release and RNA expression by activation of protease-activated receptor 1 as an underlying mechanism.
Busch et al. (Fri,) studied this question.
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