What question did this study set out to answer?

This letter aims to explore the changes in the transcriptome of the anterior cingulate cortex (ACC) in IBS rats treated with electroacupuncture to understand underlying mechanisms.

April 12, 2026Open Access

Transcriptome Changes of ACC in IBS Rats Induced by Electroacupuncture: Exploration of Mechanism and Clinical Significance Letter

Key Points

This letter aims to explore the changes in the transcriptome of the anterior cingulate cortex (ACC) in IBS rats treated with electroacupuncture to understand underlying mechanisms.
Induced IBS in rat models using established protocols.
Applied electroacupuncture treatment to assess changes in the ACC.
Conducted transcriptome analysis on tissue samples to evaluate gene expression changes.
Identified significant alterations in the transcriptome of the ACC post-treatment.
Highlighted gene pathways involved in pain modulation and gastrointestinal functions.
Suggests potential clinical significance for using electroacupuncture in IBS management.

Abstract

Jingting Zhao,1 Xiangming Ye,1 Xinyun Li2 1Center for Rehabilitation Medicine, Rehabilitation Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial Peoples Hospital, Affiliated Peoples Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, Peoples Republic of China; 2School of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, 310059, Peoples Republic of ChinaCorrespondence: Xinyun Li, School of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, 311399, Peoples Republic of China, Tel +86 18069783240, Email lxy520yeah@163.com Xiangming Ye, School of Rehabilitation, Hangzhou Medical College, Center for Rehabilitation Medicine, Rehabilitation Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial Peoples Hospital, Affiliated Peoples Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 311399, Peoples Republic of China, Tel +86 13750814756, Email yexiangming@hmc.edu.cn

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Transcriptome Changes of ACC in IBS Rats Induced by Electroacupuncture: Exploration of Mechanism and Clinical Significance Letter

Key Points

Abstract

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