Microdosimetric kinetic model for enhanced estimation of cell survival in aerobic human salivary gland cells under heavy ion irradiation

Key Points

• The aim is to improve predictions of cell survival in human salivary gland cells exposed to heavy ion radiation.
• Proposed a new microdosimetric kinetic (MK) model with an LET-dependent quadratic coefficient.
• Conducted analyses under high-LET and wide-dose conditions.
• The modified MK model shows substantially improved predictive accuracy.
• The new model maintains the simplicity and compatibility of the original MK framework.