Few studies investigated the association of newly occurring indexes of obesity and dyslipidemia including atherogenic index of plasma (AIP), body roundness index (BRI), waist-to-height ratio (WHtR) with new-onset stroke in the British population among older adults. We utilized data from Wave 6 of the ELSA (the English Longitudinal Study of Ageing), with an initial pool of 4033 participants. New incidence of stroke was captured from self-report questionnaires at Waves 7 to 9 (2014–2019). For comparability, the continuous indices (AIP, BRI, and WHtR) were converted to z-scores. Correlation analysis and multivariate logistic regression were performed on these indices. Generalized additive models (GAMs) and subgroup analyses were used to identify linear relationships. 107 subjects had experienced stroke (2.7% of total subjects). Greater AIP-Z, BRI-Z, and WHtR-Z were each independently associated with an increased risk of stroke OR 1.42 (95% CI 1.16 to 1.74) for AIP-Z; OR 1.32 (1.09 to 1.59) for BRI-Z; OR 1.33 (95% CI 1.09 to 1.63) for WHtR-Z. Quartiles were shown in trends between AIP-Z (P-trend = 0.003), BRI-Z (P-trend = 0.032) and WHtR-Z (P-trend = 0.032). GAMs confirmed linear associations between these indices and stroke risk. The associations were more pronounced in participants aged < 65 years and in females, as well as in smokers, drinkers, and those without diabetes or hypertension. Results are robust under sensitivity analysis. In this observational study of English adults aged ≥ 50 years, the newly identified parameters AIP, BRI and WHtR showed positive linear associations with new-onset stroke risk, with a more prominent epidemiological association observed in younger elderly individuals and females. These findings provide preliminary epidemiological insights into the link between such anthropometric and metabolic parameters and stroke risk, which may inform future epidemiological studies.
Yu et al. (Thu,) studied this question.