What question did this study set out to answer?

The research aims to establish a novel relay reduction and cyclization strategy for synthesizing cyclopropanes and spirocyclic γ-lactams.

April 12, 2026

Synthesis of Cyclopropane and Spirocyclic γ-Lactams via Relay Reduction and Radical–Polar Crossover Cyclization

Key Points

The research aims to establish a novel relay reduction and cyclization strategy for synthesizing cyclopropanes and spirocyclic γ-lactams.
Developed a RPCC/RPCCC cascade cyclization strategy.
Utilized CO2• - for photocatalytic cycles.
Targeted the continuous reduction of aldehydes and imines.
Achieved efficient synthesis of β-hydroxycyclopropanes.
Introduced spirocyclopropane-γ-lactams as a product.
Demonstrated broad substrate applicability and mild reaction conditions.

Abstract

A RPCC/RPCCC cascade cyclization strategy has been successfully established for the continuous reduction of electrophilic aldehydes and imines through a CO2• --mediated off-cycle photocatalytic cycle approach. This represents the first application of the SET-HAT-SET relay process in cyclopropane synthesis. This mild method exhibits a broad substrate scope, enabling the efficient synthesis of β-hydroxycyclopropanes and spirocyclopropane-γ-lactams. This strategy offers a viable approach for introducing 3D framework moieties into complex compounds.

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Synthesis of Cyclopropane and Spirocyclic γ-Lactams via Relay Reduction and Radical–Polar Crossover Cyclization

Key Points

Abstract

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