Exosomal miR‐1246 in Syphilis Serofast State: Diagnostic Value and NLRP3 Inflammasome Suppression | Synapse
April 12, 2026Open Access
Exosomal miR‐1246 in Syphilis Serofast State: Diagnostic Value and NLRP3 Inflammasome Suppression
Key Points
The research aims to evaluate the role of exosomal miR-1246 in the pathogenesis of syphilis serofast state and its potential as a diagnostic biomarker.
Assessed exosomal miR-1246 levels in syphilis serofast state samples.
Evaluated its effect on NLRP3 inflammasome activity.
Compared diagnostic accuracy with RPR (Rapid Plasma Reagin) tests.
Exosomal miR-1246 levels are significantly elevated in patients with syphilis serofast state.
MiR-1246 appears to inhibit NLRP3 inflammasome activation.
Combining miR-1246 detection with RPR enhances its diagnostic accuracy.
Abstract
Exosomal miR-1246 is elevated in SF and may contribute to its pathogenesis by inhibiting NLRP3 inflammasome. It demonstrates potential as a diagnostic biomarker, particularly when combined with RPR.