CO₂-Enabled Electrochemical Selective Deuterodefluorination of β,γ-Unsaturated α,α-Difluoroesters with Tunable Alkene Deuteration

Key Points

• The research aims to explore a new method for deuterodefluorination of difluoroesters using CO₂ in an electrochemical process.
• Utilized electrochemical techniques to facilitate selective deuteration.
• Focused on β,γ-unsaturated α,α-difluoroesters as substrates.
• Characterized the reaction products to assess site-selectivity.
• Successfully achieved site-selective deuteration of difluoroesters.
• Showed potential for tunable alkene deuteration, enhancing labeling precision.
• Demonstrated a non-reliance on precious metals for the process.