Identifies a potential mechanism (HIF-1/Angptl4 pathway) by which chronic intermittent hypoxia in sleep apnea contributes to atherosclerosis.
HIF-1-mediated increase in adipose Angptl4 and the ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea.
Drager et al. (Fri,) studied this question.