What question did this study set out to answer?

To explore the occurrence of localized bullous pemphigoid in areas previously treated with radiation during immune checkpoint inhibitor therapy.

April 13, 2026

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Localized Bullous Pemphigoid Arising within Sites of Radiation in the Context of Immune Checkpoint Inhibitor Therapy

WWW Austin Wyant LDLara DrakeBeth Israel Deaconess Medical Center AJAntonio Ji-XuBrigham and Women's Hospital

Key Points

To explore the occurrence of localized bullous pemphigoid in areas previously treated with radiation during immune checkpoint inhibitor therapy.
Case series analysis of patients with localized bullous pemphigoid
Review of radiation history and immune checkpoint inhibitor use.
Examination of skin lesions and treatment response.
Localized bullous pemphigoid developed in all patients within irradiated skin areas.
Concomitant immune checkpoint inhibitor therapy may play a role in this localization.
Minimal literature previously documented these specific cases.

Abstract

There is minimal literature on the development of localized bullous pemphigoid exclusively in previously irradiated skin. Here we report a case series of bullous pemphigoid strikingly localized to areas of previous radiation therapy occurring in the setting of concomitant immune checkpoint inhibitor therapy.

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Cite This Study

Wyant et al. (Wed,) studied this question.

synapsesocial.com/papers/69dc88d83afacbeac03ea9b9 https://doi.org/https://doi.org/10.1093/ced/llag156

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