What question did this study set out to answer?

To evaluate the effect of methylene blue mouthwash on pain associated with oral mucositis in cancer patients.

April 13, 2026

Methylene Blue Mouthwash for Oral Mucositis Pain in Cancer: An Open-Label, Non-Randomized Study

Key Points

To evaluate the effect of methylene blue mouthwash on pain associated with oral mucositis in cancer patients.
Conducted an open-label, non-randomized trial
Administered methylene blue mouthwash to participants
Compared pain levels to those using standard mouthwash
Observed short-term pain reductions in oral mucositis
Pain reduction was similar to that achieved with standard mouthwash
Findings indicate feasibility and tolerability of methylene blue mouthwash

Abstract

In this non-randomized study, MB mouthwash was associated with short-term pain reductions in OM-related pain similar to standard-of-care mouthwash. These findings support feasibility and tolerability and underscore the need for larger randomized trials.

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Methylene Blue Mouthwash for Oral Mucositis Pain in Cancer: An Open-Label, Non-Randomized Study

Key Points

Abstract

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