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The PTEN/NRF2 Axis Promotes Human Carcinogenesis | Synapse

June 3, 2014Open Access

The PTEN/NRF2 Axis Promotes Human Carcinogenesis

Key Points

Key points are not available for this paper at this time.

Abstract

Increased activity of NRF2 due to loss of PTEN is instrumental in human carcinogenesis and represents a novel therapeutic target.

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Rojo et al. (Tue,) studied this question.

synapsesocial.com/papers/69dcb324c099bcfdbb1332e5 https://doi.org/https://doi.org/10.1089/ars.2014.5843

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.1997 · 701 citations
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4Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features2010 · 428 citations
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