What are the structural, functional, and molecular changes associated with the progression of diabetic cardiomyopathy over 5 years?
The progression of diabetic cardiomyopathy is characterized by worsening myocardial mechanics and hypertrophy that are independent of glycemic control and driven by miR122-5p-mediated extracellular matrix changes.
Within 5 years of diabetic cardiomyopathy onset, increasing cardiac hypertrophy is associated with progressive impairment in strain, depletion of the compensatory role of torsion, and changes in viscoelastic contraction dynamics. These changes are independent of glycemic control and paralleled by the up-regulation of specific microRNAs targeting the extracellular matrix. (Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes CECSID; NCT00692237).
Pofi et al. (Thu,) studied this question.