January 31, 1997

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

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Abstract

What causes Alzheimer's disease? Selkoe's Perspective reviews recent research identifying four different genetic causes of Alzheimer's disease and suggests that all four point toward the deposition of amyloid beta in the brain as the initial trigger for the disease.

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Cite This Study

Dennis J. Selkoe (Fri,) studied this question.

synapsesocial.com/papers/69dd39ec99c691022d99b7de https://doi.org/https://doi.org/10.1126/science.275.5300.630

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology1996 · 487 citations
2Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor1993 · 911 citations
3Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state1993 · 1,427 citations
4Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions1993 · 1,114 citations
5Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production1992 · 1,749 citations

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