November 3, 2011Open Access

The Dietary Phase 2 Protein Inducer Sulforaphane Can Normalize the Kidney Epigenome and Improve Blood Pressure in Hypertensive Rats

GSGamarallage Vijitha Kumara SenanayakeUniversity of Miyazaki ABAli BanigeshUniversity of Benghazi LWLingyun WuUniversity of Georgia

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Abstract

Sulforaphane administration rectified pathological abnormalities in SHRSP kidneys and significantly improved blood pressure. This was associated with normalization of global kidney DNA methylation suggesting that DNA methylation could be associated with hypertension.

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Senanayake et al. (Thu,) studied this question.

synapsesocial.com/papers/69dd543f80eea7d3f699b793 https://doi.org/https://doi.org/10.1038/ajh.2011.200

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