Does sunitinib malate treatment lead to heart failure and left ventricular dysfunction?
Sunitinib malate treatment is associated with heart failure and left ventricular dysfunction, necessitating careful cardiac monitoring and aggressive hypertension control.
These observations suggested that sunitinib-associated heart failure may represent a potentially serious toxicity and underscore the need for careful monitoring of cardiac function and aggressive control of hypertension in these patients. Studies to elucidate potential mechanisms of heart failure and left ventricular dysfunction resulting from treatment with sunitinib are necessary to develop strategies for prevention and treatment of this complication.
Khakoo et al. (Thu,) studied this question.