March 31, 2022Open Access

Lactobacillus reuteri improves function of the intestinal barrier in rats with acute liver failure through Nrf-2/HO-1 pathway

QZQihui ZhouGerman Center for Neurodegenerative Diseases FWFengtian WuNational Clinical Research Center for Digestive Diseases SCShiwei ChenDuke-NUS Medical School

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Abstract

Overall, our study indicated that L. reuteri-induced expression of intestinal tight junction proteins is mediated by the PI3 K/Akt-Nrf-2/HO-1-NF-κB and PKC-Nrf-2/HO-1-NF-κB pathways, which leads to inhibition of the apoptosis of intestinal epithelial cells, thus maintaining the integrity of the damaged intestinal barrier.

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Zhou et al. (Thu,) studied this question.

synapsesocial.com/papers/69dedf3d40ea065679559ae5 https://doi.org/https://doi.org/10.1016/j.nut.2022.111673

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