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Crystals are materials in which atoms, ions, or molecules are arranged in a periodic and ordered three-dimensional structure. Among novel crystalline nanomaterials, self-assembled DNA crystals form via the base-pair complementarity of DNA molecules. Unlike traditional ionic or metallic crystals, self-assembled DNA crystals offer high programmability, enabling the design of addressable frameworks with tunable pore sizes for host-guest interactions and further functionalization through interfacial chemical modifications. Over the past 15 years, research interest in DNA nanotechnology and DNA self-assembled nanomaterials has surged. This review provides a comprehensive overview of the design principles, regulation, and functionalization of self-assembled DNA crystals for applications in molecular recognition, catalysis, and photonic crystals, while also addressing their emerging challenges within the broader context of nucleic acid chemistry and structural DNA nanotechnology.
Li et al. (Tue,) studied this question.