April 18, 2020Open Access

Penetrance of Breast and Ovarian Cancer in Women Who Carry a BRCA1/2 Mutation and Do Not Use Risk-Reducing Salpingo-Oophorectomy: An Updated Meta-Analysis

JCJinbo ChenCentral South University EBEunchan BaePenn Center for AIDS Research LZLingjiao ZhangWarren County Community College

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Abstract

The report updates penetrance estimates for BRCA1/2-associated cancer. We report higher estimates than previously reported, which did not adjust for RRSO. Differential use of RRSO may partially explain heterogeneity in the currently available penetrance estimates. For some individuals, using our estimates in BRCAPRO may result in changes in estimated carrier probabilities, which warrants validation in future studies.

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Chen et al. (Sat,) studied this question.

synapsesocial.com/papers/69df4f4944b0122c4f7a185e https://doi.org/https://doi.org/10.1093/jncics/pkaa029

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