Feasibility of improving sLe(a)/CA 19-9 harmonization by recalibration: a simulation study using three EQA programs

Key Points

• The study aims to evaluate the feasibility of recalibrating CA 19-9 harmonization across clinical assays.
• Simulation across three different external quality assurance programs (EQA)
• Assessment of correlation among CA 19-9 results pre- and post-recalibration
• Evaluation of overall harmonization effectiveness
• CA 19-9 harmonization showed improvement post-recalibration
• Significant lack of correlation in some assay results remained
• Feasibility of achieving reliable harmonization is questionable