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April 16, 2026Open Access

The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Patients Undergoing On-Pump Cardiac Surgery: A Randomized Controlled Trial

Key Points

This research aims to evaluate the impact of preoperative oral carbohydrate loading on insulin resistance in patients undergoing cardiac surgery.
Conducted a randomized controlled trial
Included adult patients undergoing on-pump cardiac surgery
Administered oral carbohydrate loading before surgery
Measured perioperative glucose and HOMA-IR levels
No significant effect on perioperative glucose levels and HOMA-IR
Carbohydrate loading did not counteract CPB-induced insulin resistance
Carbohydrate loading may result in a flatter insulin trajectory

Abstract

Preoperative oral carbohydrate loading did not significantly affect perioperative glucose or HOMA-IR in cardiac surgery. While insufficient to counteract the magnitude of CPB-induced insulin resistance, carbohydrate loading may modestly stabilize metabolic responses, as reflected by a flatter insulin trajectory.

The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Patients Undergoing On-Pump Cardiac Surgery: A Randomized Controlled Trial

Key Points

Abstract

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