Taurine mitigates bisphenol A-induced maternal-fetal oxidative stress and improves fetal weight by regulating Nrf2-Keap1 pathway, gut microbiota and bile acid metabolism

Key Points

• This research aims to explore how taurine affects oxidative stress and fetal growth under Bisphenol A exposure.
• Examined the impact of taurine on maternal-fetal oxidative stress and fetal weight.
• Analyzed the regulation of the Nrf2-Keap1 pathway.
• Studied the role of gut microbiota and bile acid metabolism in this context.
• Taurine administration reduced oxidative stress levels in mothers exposed to BPA.
• Improved fetal weight was observed with taurine treatment.
• Regulatory effects on the Nrf2-Keap1 pathway, gut microbiota, and bile acid metabolism were noted.