What is the clinical evidence from this study?

Study design: Cohort. Population: severe aortic stenosis (n=303). Intervention: CALLY index vs. High CALLY index. Primary outcome: all-cause mortality (HR 3.80, 95% CI 2.03-7.11, p=<0.001).

What does this research mean for the field?

A low C-reactive protein–albumin–lymphocyte (CALLY) index is an independent predictor of all-cause mortality in patients after transcatheter aortic valve implantation (TAVI). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate the CALLY index's ability to predict all-cause mortality after TAVI for severe aortic stenosis.

April 17, 2026Open Access

Prognostic Value of the CALLY Index in Predicting All-Cause Mortality After Transcatheter Aortic Valve Implantation: A Two-Year Follow-Up Study

Q: What are the key findings of this study?

A low C-reactive protein–albumin–lymphocyte (CALLY) index was an independent predictor of all-cause mortality after TAVI (HR 3.80; 95% CI 2.03–7.11; p < 0.001).

Q: What does this research mean for the field?

A low C-reactive protein–albumin–lymphocyte (CALLY) index is an independent predictor of all-cause mortality in patients after transcatheter aortic valve implantation (TAVI). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

Investigate the CALLY index's ability to predict all-cause mortality after TAVI for severe aortic stenosis.

Key Result

A low C-reactive protein–albumin–lymphocyte (CALLY) index was an independent predictor of all-cause mortality after TAVI (HR 3.80; 95% CI 2.03–7.11; p < 0.001).

Key Points

Investigate the CALLY index's ability to predict all-cause mortality after TAVI for severe aortic stenosis.
Retrospective single-center study of 303 patients undergoing TAVI
Calculated the CALLY index and other prognostic scores at baseline
Followed patients for a median of 21 months
Primary endpoint was all-cause mortality
60 patients (19.8%) died during follow-up
CALLY index showed highest predictive performance with an AUC of 0.698
Low CALLY index remained an independent predictor of mortality (HR: 3.80)
Kaplan–Meier analysis confirmed worse survival in the high-risk group

Study Design

Type

Cohort (n=303)

Multicenter

Structured PICO

Does the baseline CALLY index predict all-cause mortality in patients undergoing TAVI for severe aortic stenosis?

Population

303 patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis.

Intervention

CALLY (C-reactive protein–albumin–lymphocyte) index assessment at baseline

Outcome

All-cause mortalityhard clinical

A low baseline CALLY index is a strong, independent predictor of all-cause mortality in patients undergoing TAVI, offering a potential complementary biomarker for risk stratification.

Main Result

Effect estimate: HR 3.80 (95% CI 2.03-7.11)

p-value: p=<0.001

Abstract

Background and Objectives: This study investigated the prognostic value of the C-reactive protein–albumin–lymphocyte (CALLY) index in predicting all-cause mortality among patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. Materials and methods: This retrospective single-center study included 303 patients who underwent TAVI. The CALLY index and other established prognostic scores were calculated at baseline. Patients were followed for a median of 21 months. The primary endpoint was all-cause mortality. Results: A total of 60 patients (19.8%) died during follow-up. The CALLY index demonstrated the highest predictive performance for all-cause mortality, with an AUC of 0.698 (95% CI: 0.628–0.768, p < 0.001). In multivariate Cox regression, a low CALLY index remained an independent predictor of mortality (HR: 3.80, 95% CI: 2.03–7.11, p < 0.001), along with reduced LVEF, chronic kidney disease, and diabetes mellitus. Kaplan–Meier analysis further confirmed markedly worse survival in the high-risk group (log-rank p < 0.001). Conclusions: The CALLY index was independently associated with mortality after TAVI and may represent a complementary biomarker for risk stratification in this population.