Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset

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Abstract

Steeper rates of increase in pTau and GFAP among amyloid-positive individuals. After amyloid onset, steeper increases in pTau and NfL concentrations in men than in women. Steeper declines in brain volume and cognition in men corroborate biomarker results.

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Authors

Cassandra M Joynes

National Institutes of Health

Murat Bilgel

National Institutes of Health

Yang An

Chinese Academy of Medical Sciences & Peking Union Medical College

Journals

Alzheimer s & Dementia

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Institutions

Johns Hopkins University

University College London

Johns Hopkins Medicine

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Joynes et al. (Thu,) studied this question.

synapsesocial.com/papers/69e2a799be8dae5666d37b5a — DOI: https://doi.org/10.1002/alz.14405

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Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset

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Abstract

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