Complete lymph node dissection vs observation in patients with cutaneous melanoma and positive sentinel lymph node biopsy with high-risk criteria: multicenter analysis in hospitals in the Mediterranean area | Synapse
April 18, 2026Open Access
Complete lymph node dissection vs observation in patients with cutaneous melanoma and positive sentinel lymph node biopsy with high-risk criteria: multicenter analysis in hospitals in the Mediterranean area
Key Points
This analysis aims to compare the outcomes of complete lymph node dissection versus observation in melanoma patients with high-risk positive sentinel lymph node biopsy.
Multicenter analysis conducted in Mediterranean hospitals
Comparison of outcomes between patients undergoing complete lymph node dissection and those observed
Data collection on survival rates and locoregional recurrence rates
No significant survival benefit observed from complete lymph node dissection compared to observation
Incidence of locoregional recurrence was similar in both treatment groups
Abstract
In patients with melanoma and positive high-risk SLNB, CLND does not appear to confer a significant survival benefit or prevent locoregional recurrence.