Shake‐Induced Temporary Ion‐Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies

Key Points

• The aim is to investigate how temporary ion-pairing between lecithin and glycolic acid improves exfoliation in a biphasic serum.
• Conducted ex vivo and in vivo randomized studies
• Tested the efficacy of the biphasic serum
• Compared safety profiles against traditional formulations
• Enhanced exfoliation efficacy observed compared to standard glycolic acid systems
• Superior safety profile reported for consumer applications
• Temporary ion-pairing effectively overcomes pH-dependent limitations of glycolic acid