Colon microenvironment restorative nano-armored probiotics–rosmarinic acid bioconjugation for synergistic alleviation of inflammatory bowel disease

Key Points

• The main aim is to create a bioconjugated product that effectively delivers probiotics to alleviate symptoms of IBD.
• Developed a nano-armored formulation combining probiotics and rosmarinic acid.
• Assessed the effectiveness of oral administration for delivering probiotics to the colon.
• Evaluated the impact on inflammation associated with IBD.
• The nano-armored probiotics effectively delivered to the colon.
• Significant alleviation of inflammatory symptoms in models of IBD observed.