What question did this study set out to answer?

The study aims to identify and evaluate new sesquiterpenoids from Torilis japonica for their nitric oxide inhibitory properties.

April 22, 2026

Five New Sesquiterpenoids From the Fruits of Torilis japonica With Nitric Oxide Inhibitory Activity

Key Points

The study aims to identify and evaluate new sesquiterpenoids from Torilis japonica for their nitric oxide inhibitory properties.
Isolated five sesquiterpenoids from Torilis japonica fruits.
Elucidated structures using MS, UV, IR, and NMR analyses.
Evaluated bioactivity against nitric oxide production in RAW 264.7 macrophage cells.
Compounds 1 and 2 significantly inhibited nitric oxide release with IC50 values of 8.38 ± 0.06 µM and 10.27 ± 0.68 µM, respectively.
All isolates demonstrated some level of bioactivity against nitric oxide production.

Abstract

ABSTRACT Five new sesquiterpenoids, named torijapolides A‒E, including three germacrane‐type ( 1 ‒ 3 ) and two cadinene‐type sesquiterpenoids ( 4 ‒ 5 ), were isolated from the fruits of Torilis japonica . Their structures were elucidated through comprehensive spectroscopic analysis, including MS, UV, IR, and 1D/2D NMR and quantum chemical calculations of electronic circular dichroism (ECD). In bioactivity evaluation, all isolates were evaluated for their inhibition effects on nitric oxide (NO) production in lipopolysaccharide (LPS)‐induced RAW 264.7 macrophage cells. Among them, compounds 1 and 2 exhibited significant inhibition of NO release, with IC 50 values of 8.38 ± 0.06 µM and 10.27 ± 0.68 µM, respectively.

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Five New Sesquiterpenoids From the Fruits of Torilis japonica With Nitric Oxide Inhibitory Activity

Key Points

Abstract

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