Predictors of relapse and drivers of damage in SLE-associated thrombocytopenia: a long-term cohort study with comparative literature analysis

Key Points

• Identify factors that predict relapse and contribute to long-term damage in thrombocytopenia associated with systemic lupus erythematosus (SLE).
• Conducted a long-term cohort study with comparative literature analysis.
• Assessed associations between aPL positivity and thrombocytopenia relapse.
• Evaluated long-term organ damage related to glucocorticoid treatment.
• aPL positivity correlates with increased relapse rates of thrombocytopenia in SLE.
• Severe thrombocytopenia is linked to potential bleeding complications.
• Cumulative glucocorticoid exposure is associated with long-term organ damage.