What question did this study set out to answer?

The research aims to identify intolerance of uncertainty as a predictor of anxiety and depression in adolescents over time.

April 23, 2026Epidemiology and Psychiatric Sciences1 citationsOpen Access

Intolerance of uncertainty as a prospective predictor of generalized anxiety and depression in adolescents: evidence from a three-wave, 12-month study

HYHaoxian YeSouth China Normal University LZLinmao ZouCentre for Research and Development ZSZixuan ShaoSouth China Normal University

Key Points

The research aims to identify intolerance of uncertainty as a predictor of anxiety and depression in adolescents over time.
Conducted a three-wave longitudinal study over 12 months
Assessed adolescents for symptoms of anxiety and depression
Evaluated intolerance of uncertainty as a transdiagnostic predictor
Intolerance of uncertainty predicted increased symptoms of generalized anxiety and depression.
Interventions aimed at reducing intolerance of uncertainty may lower internalizing risk.
This finding supports the use of intolerance of uncertainty as a screening marker.

Abstract

IU emerged as a transdiagnostic longitudinal predictor of generalized anxiety and depressive symptoms in adolescents, supporting its value as an early screening marker of vulnerability. Interventions targeting IU may offer an effective strategy for reducing broad internalizing risk during this critical developmental period.

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