Restoration of Exosomal miR-125b, lncRNA TUG1 and lncRNA NEAT1 Homeostasis by Vitamin D in Polycystic Ovary Syndrome: Insights from an Experimental Rat Study

Polycystic ovary syndrome (PCOS) is a disease of ovarian dysfunction, hyperandrogenism and metabolic disorders in which exosomal noncoding RNAs have been reported to play a key role in its development. Vit-D (Vit-D) is known to modulate ovarian and systemic metabolism, but the impact of Vit-D on exosomal RNA networks has not been well studied. Thus, this work evaluated the regulatory role of Vit-D supplementation on exosomal microRNA (miR-125b) and long non-coding RNAs (Lnc-TUG1, Lnc-NEAT1) in PCOS rat model, offering potential mechanisms by which dietary intervention influences molecular regulation.