Protein-mediated and mechanochemical coupling strategy for the discovery and regulation of solid forms of the active pharmaceutical ingredient, trelagliptin

Key Points

• The aim is to develop a strategy for discovering and regulating solid forms of trelagliptin to enhance its effectiveness and safety.
• Utilized a protein-mediated strategy for form discovery.
• Applied mechanochemical coupling techniques to control solid-state forms.
• Employed quantitative assessments of physicochemical properties.
• Achieved precise control over the solid-state forms of trelagliptin.
• Demonstrated improvement in the physicochemical behaviour of the active ingredient.
• Identified scalable methods suitable for pharmaceutical applications.