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April 24, 2026Blood Research0 citationsOpen Access

Prognostic significance of PNH clones in aplastic anemia treated with immunosuppression or allogeneic HSCT: a 20-year single-center experience

AHAlfadil HaroonHAHazzaa AlzahraniMSM Ismail Saleh

Key Points

  • The study aims to explore the significance of PNH clones in patients with aplastic anemia treated with immunosuppression or HSCT.
  • Analyzed patient outcomes over a 20-year period at a single center.
  • Evaluated survival rates in relation to the presence of PNH clones and treatment modalities.
  • PNH clones were linked to improved survival rates following immunosuppression.
  • Lower incidence of chronic graft-versus-host disease (GVHD) was observed in patients with PNH clones after HSCT.

Abstract

The presence of a PNH clone in AA was associated with superior survival following IST and a lower incidence of chronic GVHD following HSCT. These findings suggest that PNH positivity may serve as a prognostic and immunomodulatory biomarker in AA and support its integration into therapeutic decision-making and risk stratification algorithms.

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Cite This Study

Haroon et al. (2026) studied this question.

synapsesocial.com/papers/69eb0c39553a5433e34b59b7https://doi.org/10.1007/s44313-026-00136-3
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