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Observational study identifies PNH positivity as a prognostic biomarker in aplastic anemia, indicating improved outcomes.
The presence of a PNH clone in AA was associated with superior survival following IST and a lower incidence of chronic GVHD following HSCT. These findings suggest that PNH positivity may serve as a prognostic and immunomodulatory biomarker in AA and support its integration into therapeutic decision-making and risk stratification algorithms.
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Haroon et al. (2026) studied this question.
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