Prognostic significance of PNH clones in aplastic anemia treated with immunosuppression or allogeneic HSCT: a 20-year single-center experience

Key Points

• The study aims to explore the significance of PNH clones in patients with aplastic anemia treated with immunosuppression or HSCT.
• Analyzed patient outcomes over a 20-year period at a single center.
• Evaluated survival rates in relation to the presence of PNH clones and treatment modalities.
• PNH clones were linked to improved survival rates following immunosuppression.
• Lower incidence of chronic graft-versus-host disease (GVHD) was observed in patients with PNH clones after HSCT.