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December 8, 2025Blood

Prognostic significance of PNH clones in aplastic anemia treated with immunosuppression or allogeneic HSCT

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Authors

AHAlfadil HaroonAAAbdullah AlamerAHAmr Hanbali

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Overview

Retrospective analysis reveals PNH clones improve survival in aplastic anemia patients receiving HSCT or IST, suggesting prognostic significance.

Key Points

  • Investigate the prognostic significance of PNH clones in patients with aplastic anemia treated with immunosuppression or HSCT.
  • Retrospective analysis of 207 aplastic anemia patients treated at a single institution
  • Categorized patients based on PNH clone status (positive or negative)
  • Outcomes measured included overall survival, event-free survival, and incidence of GvHD.
  • OS at 5 years for IST: 100% in PNH-positive vs 72.4% in PNH-negative (p = 0.004)
  • Event-free survival at 5 years: 60% in PNH-positive vs 37.6% in PNH-negative (p = 0.08)
  • Chronic GvHD incidence: 4% in PNH-positive vs 27% in PNH-negative (p = 0.01)

Cite This Study

Haroon et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df72https://doi.org/10.1182/blood-2025-4967
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