Background. Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder affecting skeletal and dental tissues. The aim: to assess the dental status and content of vitamin D, osteocalcin, osteoprotegerin, bone alkaline phosphatase, and parathyroid hormone in mixed saliva, and to study the relationship between clinical and laboratory parameters and bone tissue status in children with osteogenesis imperfecta. Materials and Methods: A study was conducted at the Department of Pediatric Dentistry "CS and Maxillofacial Surgery" of the A.I. Evdokimov Scientific Research Institute of Dentistry. The study involved 20 apparently healthy children (health groups 1 and 2) aged 8–17 years (average age 12 years) seeking dental care (comparison group) and 26 children of the same age with a genetically diagnosed condition, osteogenesis imperfecta (study group), referred from the GMSClinic in Moscow. The study was approved by the Ethics Committee of the Russian University of Medicine (Extract from Protocol No. 02-24 of the Interuniversity Ethics Committee dated February 15, 2024). The study consisted of clinical and biochemical phases. The dental status was assessed using standard dental indices. The content of mineralization markers in mixed saliva was determined using enzyme-linked immunosorbent assay (ELISA). Results: Compared with healthy children, children with osteogenesis imperfecta had higher dental status indicators associated with a deficiency of vitamin D and bone metabolism regulatory factors (ABP, OST, TFR), possibly indicating impaired mineralization of the skeleton, dental tissues, and periodontium in children with this pathology. From a clinical point of view, the established relationships between the studied clinical and laboratory parameters determine the need to classify children with imperfect osteogenesis as a high-risk group for dental problems.
Alekseeva et al. (Sun,) studied this question.