Psoriasis is an autoimmune disease affecting more than 7.5 million adults in the United States and is associated with an increased risk of psoriatic arthritis and an impaired quality of life. An estimated 40%–50% of patients with psoriasis have psoriatic nail disease, which can present as nail pitting, subungual hyperkeratosis, nail dystrophy, and oil spots. Nail psoriasis often leads to a decrease in the self-confidence of individuals due to its disfiguring feature, along with an increase in the frequency of depression and anxiety, negatively impacting quality of life . Psoriatic nail disease can be particularly challenging to treat with topical therapies, often requiring the use of systemic drugs for patients with more than 3 nails involved and significant skin disease. In some cases, nail psoriasis can also occur in the absence of cutaneous symptoms. We present a case report of a 33-year-old male patient with severe nail psoriasis affecting multiple fingernails and toenails who experienced significant improvement in both his nails and quality of life with risankizumab.
Rodriguez et al. (Thu,) studied this question.
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