Synthesis, and evaluation of novel low nanomolar isoindigo-based RET kinase inhibitors

Key Points

• The aim is to synthesize and evaluate new isoindigo-based inhibitors specifically targeting RET kinase.
• Synthesis of isoindigo derivatives.
• Evaluation of the inhibitory activity of 4c against RET kinase.
• 4c identified as a nanomolar selective inhibitor of RET kinase.
• Effective against the RET V804L mutant.