What question did this study set out to answer?

This research aims to develop a new method for synthesizing benzo[4,5]thiazolo[3,2-a]indoles through oxidative cyclization.

April 26, 2026Open Access

Mild PIFA-Mediated Synthesis of Benzo4,5thiazolo3,2-aindoles via Oxidative Cyclization

Key Points

This research aims to develop a new method for synthesizing benzo[4,5]thiazolo[3,2-a]indoles through oxidative cyclization.
Utilized (bis(trifluoroacetoxy)iodo)benzene (PIFA) as an oxidant
Employed straightforward cyclization of 1-(2-(methylthio)phenyl)-1H-indoles
Successfully synthesized benzo[4,5]thiazolo[3,2-a]indoles in a smooth reaction process.

Abstract

We report a novel synthetic approach for the synthesis of benzo4,5thiazolo3,2-aindoles. This strategy relies on a straightforward cyclization of 1-(2-(methylthio)phenyl)-1H-indoles using (bis(trifluoroacetoxy)iodo)benzene (PIFA) as an oxidant. The reaction proceeds smoothly...

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