April 11, 2017Open Access

Effects of fermented ginseng root and ginseng berry on obesity and lipid metabolism in mice fed a high-fat diet

Structured PICO

Population

Mice fed a high-fat diet

Intervention

Fermented ginseng root (FGR) and fermented ginseng berry (FGB) saponin

Comparator

High-fat diet alone (implied) and comparison between FGR and FGB

Outcome

Obesity and lipid metabolismsurrogate

In a mouse model of high-fat diet-induced obesity, fermented ginseng root and berry exhibited distinct metabolic and anti-inflammatory benefits.

Abstract

Saponin from both FGR and FGB had a beneficial effect on high-fat diet-induced obesity. Compared to FGB, FGR exhibited more potent antihyperglycemic and antiobesity effect. However, only FGB significantly inhibited mRNA expression of inflammatory markers such as interleukins 1β and 6 in adipose tissue.

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