Benchmarking Long-Acting Injectable Antiretroviral Therapy Against Real-World Oral Care in Southern China: A Matching-Adjusted Indirect Comparison of Global Trial Data

Key Points

• This research aims to compare long-acting injectable antiretroviral therapy outcomes with real-world oral care rates in Southern China.
• Conducted a matching-adjusted indirect comparison (MAIC) using global trial data and local oral cohorts.
• Analyzed demographic overlaps to assess effective sample size (ESS) between trial participants and local care users.
• Compared trial outcomes of long-acting injectables with matched oral care results across multiple metrics.
• Outcomes from long-acting injectable trials exceeded local oral care rates in 10 out of 11 comparisons.
• Outcome differences were significantly associated with demographic overlaps.
• Findings suggest that tailored long-acting injectable implementations may be more effective than using trial data universally.