BACKGROUND/AIM: The aim of this study was to evaluate the associations between three follicle-stimulating hormone receptor (FSHR) and FSH β subunit promoter gene polymorphisms, including Asn680Ser, -29G>A, and -211G>T with ovarian response, oocyte maturation, and embryo quality in Thai infertile women. MATERIALS AND METHODS: fertilization or intracytoplasmic sperm injection were recruited. The polymorphisms were analyzed using polymerase chain reaction - restriction fragments length polymorphism. RESULTS: =0.029). Logistic regression analysis revealed the association between Asn/Ser and S-carriers with poor response crude odds ratio (OR)= 6.33, 95% confidence interval (CI)=1.56-25.66 and 5.36, 95% CI=1.36-21.10, respectively. The associations remained after age adjustment (adjusted OR=7.71 95% CI=1.73-34.45 and 6.78, 95% CI=1.57-29.29, respectively). In contrast, -29G>A and -211G>T polymorphisms were not associated with ovarian response. There were not any associations between the three polymorphisms and oocytes maturation and embryo quality. CONCLUSION: This study is the first to report the association between Asn680Ser FSHR gene polymorphism and the risk of poor response among Thai women.
Boonlong et al. (Tue,) studied this question.
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