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Objective: This systematic review, including a meta-analysis, aimed to investigate the efficacy and safety of direct oral anticoagulants (DOACs) in preventing and resolving radial artery occlusion (RAO) following transradial artery access. Methods: We synthesized evidence from randomized controlled trials (RCTs) identified in PubMed, CENTRAL, Scopus, and Web of Science up to May 2025. Using Stata MP v. 17, we employed a fixed-effects model to report dichotomous outcomes, presenting relative risk ratio (RR) with a 95% confidence interval (CI). Trial sequential analysis (TSA) was conducted to investigate the robustness and reliability of the cumulative evidence. Results: = 0.36]. There were no incidences of arteriovenous fistula, pseudoaneurysm, or compartment syndrome throughout the trials. Conclusion: DOACs significantly prevented the incidence of RAO, although TSA indicates that this finding is not yet conclusive. No significant differences were found between groups regarding RAO resolution or the incidence of hematoma, minor bleeding, or major bleeding. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251063999.
Alsubaiei et al. (Wed,) studied this question.