Cobalt-Catalyzed Asymmetric Annulative Dienylation with Allenyl Carbinol Acetates via Desymmetrization.

Key Points

• The aim is to develop an efficient method for producing C1-chiral compounds through desymmetrization.
• Utilized cobalt catalysis for asymmetric annulative dienylation.
• Achieved high yields and excellent enantioselectivities with broad substrate generality.
• Assessed the effectiveness for synthesizing P-stereogenic cyclic phosphinamides.
• Produced 3-styryl-1,2-dihydroisoquinolines with high yields.
• Demonstrated excellent enantioselectivities, contributing to scalable synthesis.
• Successful application for accessing various P-stereogenic cyclic phosphinamides.