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Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research. | Synapse

May 3, 20260 citations

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Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research.

YHYuanyu HuangJohns Hopkins University LCLijun ChenLeidos (United States)PWPeter I-Fan WuLeidos (United States)

Key Points

The aim is to provide a comprehensive resource of cancer proteins detected via mass spectrometry.
Developed a mass spectrometric cancer protein database with provenance-aware features.
Aligned data with UniProtKB for enhanced protein identification.
Facilitated cohort-specific querying and evidence aggregation.
Enabled standardized comparisons to reference proteomes.
Improved planning for downstream assays in cancer research.

Abstract

and fragment-ion patterns. MSCP provides a provenance-aware, UniProtKB-aligned resource for cancer proteomics that supports both cohort- and model-specific querying and coverage-oriented evidence aggregation, enabling standardized comparisons to reference proteomes and facilitating downstream assay planning and translational studies.

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Cite This Study

Huang et al. (Fri,) studied this question.

synapsesocial.com/papers/69f6e60f8071d4f1bdfc6af9 https://doi.org/https://doi.org/10.1021/acs.jproteome.5c01259